The Nattokinase Supplement That Actually Delivers Clinical Doses

Why Toku Flow's soy-free formula is the only nattokinase I keep in my stack

If there’s one supplement to be bullish on in the future — it’s nattokinase.

We predict it will be the pillar of most cardiometabolic optimization stacks over the next decade. As more & more move away from the Big Pharma-sponsored solutions, they're choosing health sovereignty through powerful, naturally-occurring compounds.

My top pick to represent that future?

Toku Flow.

Last summer, I had the opportunity to speak with Justin (the founder) — this team is serious about developing products made for the elite practitioners in our health space. Their first product is a clear proof of that — combining two supplements already in my personal cardiometabolic lineup (nattokinase + MK-7) & should be in most individual’s cardioprotective stack, especially those with familial cardiac history.

Here’s how Toku separates itself from the supplement pack.

The Formula

Toku Flow combines three clinically-dosed compounds for cardiovascular support: nattokinase, vitamin K2 MK-7, & organic oat beta-glucan. Our priority in the supplement space has always been simple (but quite rare): transparency with clinically significant dosages.

Nattokinase (10,800 FU)

The 10,800 FU dosage in Toku Flow isn’t arbitrary. It’s directly informed by a large-scale clinical study involving 1,062 participants¹, where this exact dose led to exceptional cardiometabolic outcomes:

• 39% reduction in arterial plaque size

• 25% improvement in carotid artery flexibility

• 18% reduction in total cholesterol

• 17% reduction in triglycerides

If you want the full breakdown on nattokinase (every RCT/clinical trial summarized), we wrote about it at length here.

How This Japanese Protease Enzyme Is Reshaping Cardiovascular Health

Vitamin K2 MK-7 (180 µg)

K2 is most bioavailable in the MK-7 form.

A three-year trial² involving more than 240 healthy postmenopausal women showed MK-7 at 180 µg/day improved arterial stiffness.

Stiffness Index β during three-year treatment with placebo or MK-7 (open symbols)

A one-year clinical trial³ also demonstrated that MK-7 improved overall vascular health slowing the progression of arterial calcification.

Organic Oat Beta Glucan (3g)

Beta-glucan is a soluble fiber extracted from oats best known for its lipid optimizing effects.

A 2022 systematic review & meta-analysis of 14 trials⁴ found that oat beta-glucan (doses 1.5-6 g/day) lowered total cholesterol by 11.6 mg/dL & LDL by 9.7 mg/dL.

What Sets Toku Apart

In a growing nattokinase supplement market (*avoid much of Amazon*), Toku Flow distinguishes itself with efficacious dosing, transparency, & quality. Here’s how it stands out:

1. Dosing transparency: Most nattokinase caps fall into a couple categories: 1) underdosed significantly or 2) they’re hiding behind proprietary blends. Toku doses their nattokinase at more than 175% of the label claim. Any nattokinase brand that is serious about their customers’ health understands the importance of the overage concept when it comes to dosing proteolytic enzymes (see article above on why dosing nattokinase much higher is needed).

2. Soy-free nattokinase: Toku is atypical in that it’s fermented from chickpeas, not soybeans. Without soy, yet still maintains it’s full fibrinolytic activity.

3. No filler junk: Freeze-drying isolates the enzyme cleanly. No magnesium stearate. No silicon dioxide. No other flow agents.

How I Use It

Since I started supplementing with Toku in late summer 2025, it’s become a staple for my nighttime system as an easy (& delicious) bedtime hot chocolate.

Mixes well. Tastes great. And has proven effective at keeping blood pressure & LDL-C numbers low.

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The current hype of the health space is peptides & exogenous hormone replacement therapy. We see it everywhere. These absolutely have their place in many protocols, however what we’re seeing a lot of in this space is a sudden neglect of the basics of cardiometabolic health.

So a reminder is in store: Test your metabolic biomarkers (don’t guess). Build your aerobic engine. Focus on the metabolic & cardioprotective components — much else comes down stream of these.

Until next time,
Phys

1. Chen H, Chen J, Zhang F, Li Y, Wang R, Zheng Q, Zhang X, Zeng J, Xu F, Lin Y. Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants. Front Cardiovasc Med. 2022 Aug 22;9:964977. doi: 10.3389/fcvm.2022.964977. Erratum in: Front Cardiovasc Med. 2022 Dec 05;9:1076420. doi: 10.3389/fcvm.2022.1076420. PMID: 36072877; PMCID: PMC9441630.

2. Knapen MH, Braam LA, Drummen NE, Bekers O, Hoeks AP, Vermeer C. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. Thromb Haemost. 2015 May;113(5):1135-44. doi: 10.1160/TH14-08-0675. Epub 2015 Feb 19. PMID: 25694037.

3. de Vries F, Bittner R, Maresz K, Machuron F, Gåserød O, Jeanne JF, Schurgers LJ. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women. Nutrients. 2025 Feb 27;17(5):815. doi: 10.3390/nu17050815. PMID: 40077685; PMCID: PMC11901762.

4. Yu J, Xia J, Yang C, Pan D, Xu D, Sun G, Xia H. Effects of Oat Beta-Glucan Intake on Lipid Profiles in Hypercholesterolemic Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2022 May 13;14(10):2043. doi: 10.3390/nu14102043. PMID: 35631184; PMCID: PMC9147392.