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How To Stop Waking Up To Pee At Night

The 14 root causes driving nighttime urination & exactly how to address each one

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BowTiedPhys
Feb 25, 2026
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Even the self-declared world’s healthiest man runs into the issue of waking to pee at night.

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Bryan Johnson@bryan_johnson
@Astra5225 I probably only get up at night around 50% of the time or so. I stop drinking liquids at ~4pm to avoid night time urination.
6:09 PM · May 3, 2025 · 882K Views

86 Replies · 1 Repost · 192 Likes

More than a third of adults over 301 wake up to urinate at night. The condition is so common we've normalized it, but it’s still far from even normal function.

The standard advice is something like: Stop drinking water after 6 PM. Cut sodium. Front-load hydration.

You try them. They help marginally. But you're still waking up.

Because surface-level interventions never address upstream causes.

Nighttime peeing signals deeper issues.

If you’re waking even 1x to pee, there’s a high chance at least one factor outlined here is driving it.

Here’s the guide to help you stop peeing tonight.

Cause #1: Circadian Dysregulation

Your brain-kidney-bladder axis operates on a 24-hour clock. At night, circadian signals should increase arousal thresholds, melatonin, & vasopressin reducing urine production and maintaining bladder capacity. However, blunted rhythms result in higher nighttime urine production.2

Duffy et al. (2016)3 tracked urine production over 40 hours in young versus older adults. Total 24-hour output was identical, but older adults produced significantly more urine during nighttime hours.

Figure 1
Urine output as a function of time in healthy young (black line) & older (red line) adults

They explained:

“…this reduction in amplitude of the circadian rhythm of urine output with aging contributes to nocturia in otherwise healthy older adults by causing more urine to be produced during the nighttime hours than in young adults.”

Solutions

  • Minimize blue/white light post-sunset: red/amber bulbs, f.lux/Night Mode, blue blockers

  • Suppress nnEMF before bed (WiFi off, airplane mode)

  • Maximize natural light exposure at sunrise, midday, & sunset

  • Complete darkness: blackout curtains & eye mask

  • Consistent meal timing to synchronize gut microbiota circadian cycles

  • Epitalon (3-6mg before bed) → circadian amino acid complex to reset pineal gland function

Cause #2: Nervous System Dysregulation

Sympathetic hyperactivity and poor vagal tone create an overactive bladder. The imbalance increases bladder sensitivity and triggers urgency signals even when bladder volume is low.

Overactive bladder as a dysfunction of the autonomic nervous system – A  narrative review - ScienceDirect
Sympathetic & parasympathetic regulation of storage & micturition phase.

Solutions

  • Track HRV, resting heart rate, & blood pressure (relative metrics…it’s today you v. last week you)

  • Analog brain dump before bed

  • Cut social media 2 hours pre-sleep

  • 4-7-8 breathing to activate parasympathetic response

  • Magnesium (Tauromag or glycinate) + L-theanine + glycine

    • Combine all three with the PreSleep formula (Save 10% w/ PHYS10)

  • Herbal teas: chamomile, mulungu, magnolia bark

  • Sauna + cardio 2-3x weekly

Cause #3: Cold Temperatures

Every 1°C drop in bedroom temperature raises nighttime peeing odds by 7-10%.4

Association of temperature at home & pee frequency per night

Temperatures below 60°F activate TRPM8 cold-sensing channels, heightening bladder excitability. Winter exacerbates this through greater indoor-outdoor temperature differentials.

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