My main concern with the study comparing Ubiquinone and Ubiquinol head-to-head is that:
It’s a novel form of Ubiquinol (cocrystal)
It’s sponsored by the company that came up with that novel form
Assuming everything’s above board (and that #2 doesn’t matter), I am still left wondering if Ubiquinol is that much better or that form (cocrystal) is.
Right to be cautious of "novel" stuff. This is already happening in the peptide space. We're getting more and more "enhanced" versions. Simple marketing tactic being deployed for differentiation. Maybe...hard hard maybe it provides some shelf life stability but I'm not chasing it.
On the -quinol vs. -quinone - that's more where I'm focused particularly with older individuals. Bioavailability certainly better in former than the latter. Nothing new there. That limited capacity to reduce to -quinol typically comes with metabolic unhealth + age. So if you're on the younger side + leptin sensitive, then you can easily get away with a slightly higher ubiquinone dose. Even a chance it may have very little impact for you to begin with.
I just eat 250g of beef heart once a week, but that seems to be just one third of what you recommended taking per day (it's apparently around 10–15 mg CoQ10 per 100 g). Interesting
Yep typically would include a food first approach. However nothing comes into the clinically significant territory. Organ meats are closest yet still 8-10x off the mark for this one.
My main concern with the study comparing Ubiquinone and Ubiquinol head-to-head is that:
It’s a novel form of Ubiquinol (cocrystal)
It’s sponsored by the company that came up with that novel form
Assuming everything’s above board (and that #2 doesn’t matter), I am still left wondering if Ubiquinol is that much better or that form (cocrystal) is.
Right to be cautious of "novel" stuff. This is already happening in the peptide space. We're getting more and more "enhanced" versions. Simple marketing tactic being deployed for differentiation. Maybe...hard hard maybe it provides some shelf life stability but I'm not chasing it.
On the -quinol vs. -quinone - that's more where I'm focused particularly with older individuals. Bioavailability certainly better in former than the latter. Nothing new there. That limited capacity to reduce to -quinol typically comes with metabolic unhealth + age. So if you're on the younger side + leptin sensitive, then you can easily get away with a slightly higher ubiquinone dose. Even a chance it may have very little impact for you to begin with.
That makes sense and that is my overall understanding, too. Take better and more bioavailable forms as you age.
Just wish we could get a true head-to-head study without confounding variables.
I just eat 250g of beef heart once a week, but that seems to be just one third of what you recommended taking per day (it's apparently around 10–15 mg CoQ10 per 100 g). Interesting
Yep typically would include a food first approach. However nothing comes into the clinically significant territory. Organ meats are closest yet still 8-10x off the mark for this one.
Are you going to do a break down by brand?
Note the statistical significance included.