The 13 Best Health & Fitness Podcasts of 2025: Your Ultimate Year-End Guide

A curated breakdown of the hosts, episodes, & paradigm shifts that made 2025 a breakthrough year for the health space

Dec 23, 2025

It’s time to close out another year. So you know what that means: we get to run back the best health & fitness podcast episodes of 2025. In a space full of derivative slop, we’ve found these to be well worth the listen — informative, practical, & well-articulated. There’s a topic for everyone here: circadian biology, light, fertility, nutrition, VO2 max, resistance training, & more.

You’ll see a wide-range of podcasting talent. Some mainstream vets. Some rising stars. And even a few familiar bros in our corner of the health space.

Take your picks & consider your cardio queue stocked up for the next few months.

Here’s our top 13 coming out of 2025.

#13: Using Existing Drugs in New Ways to Treat & Cure Diseases of Brain & Body | Dr. David Fajgenbaum (Huberman Lab)

Summary: Dr. Fajgenbaum advocates for patient agency & systemic reform arguing modern medicine’s biggest blind spot is not the lack of drugs but the lack of systems to connect existing treatments with new diseases. With over 4,000 approved drugs but 18,000 known diseases, most medications impact dozens of biological pathways, yet are only approved for one or two. Bureaucratic, economic, & structural disincentives prevent companies and clinicians from discovering new applications once patents expire.

He cites a few remarkable examples:

Lidocaine → a common anesthetic reduces post-surgery breast cancer mortality by 29%
Viagra → ED medication treats a rare pediatric lung disease
Colchicine → an ancient gout remedy prevents heart attacks
Adalimumab → a TNF inhibitor saved children from a fatal stroke disorder once word spread globally

Fajgenbaum emphasizes the need to move from a random approach to a more integrative one — creating open databases that link biology, treatment, and outcome so no one is forced to wait for knowledge to spread.

Quotes:

“I turned to my family… and said, ‘I’m going to dedicate the rest of my life, however long that’s going to be.. to trying to find out, is there a drug out there that could help me and other patients with my disease that’s made for another condition?’”

Duration: 1 hr 59 min

#12: How to Train According to the Experts | Brady Holmer (Found My Fitness)

Summary: Brady is the author of Physiologically Speaking, a world class athlete (finished the Boston Marathon in 2 hr 24 min → superhuman), & pioneer of the Creatini. Not to mention one of the best personas on X. Light-hearted. And most importantly - knows his shit.

Some of the major highlights Brady covers:

Cardiovascular Health: 4–5 days of aerobic exercise (5–6 hours weekly), including one HIIT session, optimizes cardiovascular function. A study on 50-year-olds showed a 2-year exercise protocol reversed 20 years of cardiac aging, while the Dallas Bed Rest Study found 3 weeks of bed rest more detrimental than 30 years of aging.
Strength Maintenance: 2 resistance training sessions/week with multi-joint exercises, 1g protein/lb body weight, & 5–10g creatine suffice for strength preservation or gains.
Mortality Reduction: 1–2 minutes of vigorous activity (e.g., stair sprints) 3x daily reduces all-cause mortality by 50%.
Sauna Benefits: 2–4 weekly sauna sessions amplify cardiovascular benefits beyond exercise alone.

Quotes:

“After age 70, it becomes nearly impossible to reverse the structure of the heart, indicating you need to do everything you can before that age.”
“Focus on execution rather than perfection. Don’t get focused on the perfect sets, perfect weight - just execute week after week.”

Duration: 2 hr 53 min

#11: Do I Have Heart Disease? My Heart Scan Results | Dr. Thomas Dayspring and Dr. Dan Soffer (The Proof with Simon Hill)

Summary: Simon Hill’s recent heart scans show minimal, early-stage atherosclerosis despite a decade of strict plant-based nutrition. His physicians attribute this subclinical condition to early-life cholesterol exposure. Hill’s diet and exercise have significantly slowed disease progression, however halting or reversing it likely requires further ApoB reduction. The episode reframes cholesterol management not as a binary “natural vs. medicated” issue, but as precision prevention → balancing lifestyle, genetics, & pharmacology for lifelong heart health.

Quotes:

“You can be doing all the right things on paper, your blood tests can look excellent — and you can still be developing atherosclerosis.”
“Most of us will die with cardiovascular disease, but today we don’t have to die because of it.”
“Even at LDL 15, you’re not hurting your cells. The brain makes all the cholesterol it needs.”

Duration: 56 min

#10: Natural Ways to Boost GLP-1 with Dr. Ben Bikman (The Metabolic Classroom)

Summary: Dr. Ben Bikman explains that while GLP-1 agonists are effective for weight loss, he believes they may come with some concerning side effects including 40% of weight lost coming from lean mass, a 200% increase in depression risk, and the return of sweet cravings after 2 years when 70% of users quit the drug. He also discusses some natural ways to boost endogenous levels of GLP-1:

Yerba Mate
Allulose
Carb restriction
Deep sleep
Hydrolyzed collagen peptides

Quotes:

“Someone who’s struggling with body fat levels and struggling with obesity, part of what they struggle with may be this reduced response to what they’re eating with GLP-1.”
“The evidence is quite clear that one good way to naturally increase GLP-1 secretion is control the carbs while prioritizing protein and not fearing fat.”

Duration: 25 min

#9: Dr. Bret Contreras: How to Build Bigger Glutes & Legs (Perform with Andy Galpin)

Summary: Contreras & Galpin dissect how glute hypertrophy differs in emphasis (not biology) between genders. The key lies in training frequency, exercise selection, & understanding anatomy. The hip thrust (Contreras’ invention popularized in 2006) remains a cornerstone for glute growth due to its efficiency & low fatigue cost. The best programs blend vertical (stretch), horizontal (short), & lateral (stabilizing) exercises to fully develop the glute complex while respecting recovery.

Quotes:

“The glutes are the keystone muscle — the centerpiece of the human body.”
“Men want to grow everything — you can’t name a muscle we’ll say no to. Women? They want glutes, not bigger thighs.”
“Make it your goal to hip thrust 315 for 20 reps — that’s your ticket to big glutes.”

Duration: 3 hr 29 min

#8: How to Find & Be a Great Romantic Partner | Lori Gottlieb (Huberman Lab)

Summary: The most reliable guide to relationship compatibility isn’t “sparks” or “butterflies” but rather whether you feel calm, content, & safe in someone’s presence. Most people unconsciously seek partners who replicate childhood wounds because familiarity feels safer than uncertainty, even when familiarity means pain. The key to breaking destructive patterns lies in rewriting the faulty narratives we carry (i.e. ”I’m unlovable”, “I can’t trust anyone”), learning to respond rather than react by creating space between stimulus and response, and understanding that insight without action is worthless → you must actually change your behavior in the world, not just understand why you do things.

Quotes:

“We marry our unfinished business...if you haven’t processed whatever it was that you wanted more of or less of when you were growing up...you literally have radar for a person who is exactly like the person who hurt you but doesn’t look like that.”
“Just because someone doesn’t value you doesn’t mean you don’t have value...I think that’s a really important lesson for people to learn.”

Duration: 3 hr 23 min

#7: Strength Training for Kids & Building Lifelong Movement Skills (Perform with Andy Galpin)

Summary: Dr. Andy Galpin squashes persistent myths about youth strength training revealing that kids can safely start as young as 5-7 years old and that the real goal isn’t building maximum strength but developing “movement literacy” → coordination, balance, & creative problem-solving through varied physical activities. 80% of kids globally fail to meet basic activity standards. This creates a “death spiral” where poor movers lose confidence → withdraw from activity → become injury-prone adults. Research shows properly trained kids gain not just physical benefits but measurable improvements in intelligence, mental health, & lifelong activity patterns.

Quotes:

“The primary goal of strength training for kids should be to enhance movement literacy...Move how you want and don’t move how you don’t want. Movement options, movement variety, movement choice, unique and independent and creative ways to solve movement problems. That’s movement literacy.”

Duration: 1 hr 50 min

#6: How to Lose Fat & Gain Muscle With Nutrition | Alan Aragon (Huberman Lab)

Summary: Alan Aragon reveals that the rigid rules around protein timing, fasted training, & meal frequency are largely irrelevant. What actually matters is hitting 0.7-1.0 g/lb BW daily, maintaining appropriate total calories, & training consistently. His meta-analysis work proves the “anabolic window” is actually 48-72 hours (not minutes) & fasted vs. fed training makes little difference for fat loss when daily nutrition is equated.

Quotes:

“The things that make 90% of the difference...sleep, exercise, nutrition, light, stress management, relationships...are the things we have to do 90% of the days of our lives.”
“It’s probably more dangerous to step outside and breathe in the LA air than engage in some aspartame or sucralose on a regular basis.”

Duration: 2 hr 34 min

#5: Myths about GLP1, TRT, Fertility, & Fitness ft Alexander Cortes (AJAC Fitness) | Ep. 136 (Radical Health Radio)

Summary: Alexander Cortes, chief broscientist & Health 𝕏 legend (American creatine pioneer?), advocates for a movement-positive approach emphasizing consistency & enjoyment in training over time. He supports a balanced, Mediterranean-style diet tailored to individual needs highlighting the importance of micronutrients and moderation over extreme dietary trends. Cortes discusses the transformative potential of peptides like GLP-1 agonists for obesity & BPC-157/TB-500 for healing, alongside TRT for male vitality. His work (alongside Preethi Kasireddy) with Ferta Health focuses on addressing infertility through a metabolic, root-cause approach emphasizing: circadian alignment, stress reduction, & nutrient optimization for reproductive health.

Quotes:

“Being scientific means that you are observant of cause and effect and what’s true and what’s not…broscience means you have a bias towards real-world outcomes.”
“Testosterone replacement therapy is life-changing if you have clinical need for it…it reduces cardiovascular risk, helps retain lean body mass, and improves cardiometabolic health.”
“Being reproductively healthy is a vital sign of a healthy metabolism…the majority of infertility cases outside of structural issues are metabolic.”

Duration: 1 hr 21 min

#4: How to Enhance Your Immune System | Dr. Roger Seheult (Huberman Lab)

Summary: Dr. Roger Seheult, a pulmonologist & ICU specialist, discusses evidence-based strategies for enhancing immune function and avoiding illness through his “NEW START” framework → nutrition, exercise, water, sunlight, temperance, air, rest, & trust. Infrared (IR) light from the sun penetrates tissues, boosting mitochondrial melatonin production — 20x higher than pineal gland levels. This potent antioxidant enhances immune function, metabolism, & disease prevention. Just 15–20 minutes of daily sunlight yields significant benefits. He also explains how hydrotherapy (hot-cold contrast therapy) boosts interferon production up to 10x at fever temperatures and mechanically releases white blood cells into circulation, a protocol used successfully during the 1918 Spanish flu pandemic.

Quotes:

“After 40 years, the output of mitochondria which is ATP drops by about 70%. Can you imagine being in your house and somehow the energy production to your house drops by 70%? This is exactly what’s happening in the cell.”
“We’ve had a lot of data that shows that ultraviolet light can cause cancer and so we’ve assumed that anything that has ultraviolet light can cause cancer. There’s this complete dismissal of the fact that this ultraviolet light is packaged for the entire existence of human nature along with infrared light.”

Duration: 3 hr 28 min

#3: The Golden Age of Broscience with Silver Fox Leo

Summary: Leo (BowTiedHRT on 𝕏) shares his expertise on hormone optimization. He advocates for supraphysiologic testosterone doses (1,200–2,000 ng/dL) and balanced estrogen management to enhance libido, joint health, & longevity. He emphasizes proper macro timing (morning carbs, later fats) to boost metabolism and thyroid optimization with T3 micro-dosing for energy & vitality. Leo critiques conventional medicine’s conservative approach, encouraging individual agency through blood work, community knowledge on 𝕏, & personalized consultations.

Quotes:

“If you want your dick to work and you want to be excited about having sex and a high libido, your estrogen can’t be in the gutter.”
“The tools now available to people to be your own medicinal guide and to heal yourself or to enhance yourself, they’re just unparalleled... The only barrier is your own curiosity.”

Duration: 1 hr 51 min

#2: Why Big Pharma Wants You on SSRIS (w/ Dr. Roger McFillin)

Summary: Dr. Roger McFillin sat down with our Chad friend Noah Ryan to critique the pharmaceutical industry’s profit-driven promotion of SSRIs, which pathologizes normal emotions like anxiety and depression while ignoring risks like sexual dysfunction, suicidality, & emotional numbing. He links modern mental distress to disconnection from nature, community, & authentic experiences. McFillin advocates presence, in-person connections, & critical thinking to foster personal sovereignty emphasizing that emotions are vital signals for growth, not disorders requiring medication.

Quotes:

“The people who are happiest are the ones that are in service of others...We’re designed to be in love in connection with each other, not in fear and not in division.”
“Anything that is going to hijack your sovereignty is ultimately evil and it’s pulling you away from your divine nature.”
“There’s a 4-6x influence in becoming suicidal compared to placebo and...for a percentage of people they become violent as well.”

Duration: 1 hr 10 min

#1: The Golden Age of Broscience with Greg Mushen

Summary: Greg Mushen, a friend & prominent figure of the Health 𝕏 community, shares his transformation from mold illness driven by his commitment to his daughter. He emphasizes 17k daily steps for fat loss/mental clarity and advocates a systems-based approach using evidence-based research to optimize soluble and insoluble fiber for gut microbiome health. Greg critiques siloed science for overlooking biological connections and proposes cycling high-fiber (summer) and low-fiber (winter) diets, aligning with evolutionary and circadian rhythms → challenging the “summer cut, winter bulk” fitness model.

Quotes:

“If you know how everything integrates, how everything connects, then it’s like you have 10x the power.”
“The more that you can know the truth... the more rich your life can become and the more that you can engage in the world.”

Duration: 1 hr 42 min

That rounds out this year’s podcast banger list. Queue them up for your steady-state cardio sessions in the new year. Drop any you think are worth the listen I missed here in the comments below.

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